Chandra Health Dictionary

Chandra: From 1 Different Sources


(Hindi) Of the moon; another name for the goddess Devi Chandara, Chandria, Chaundra, Chandrea, Chandreah
Health Source: Medical Dictionary
Author: Health Dictionary

Cinnamomum Camphora

(Linn.) Nees & Eberm.

Family: Lauraceae.

Habitat: A tree native to China and Japan and often grown as a hedge plant.

English: Camphor tree.

Ayurvedic: Karpura, Ghanasaara, Chandra, Chandra Prabhaa, Sitaabhra, Hima-valukaa, Hi- mopala, Himakara, Shashi, Indu, Tushaara, Gandhadravya, Shital- raja.

Unani: Kaafoor.

Siddha/Tamil: Indu, Karupporam.

Action: Camphor taken internally in small doses (toxic in large doses) acts as a carminative, reflex expectorant and reflex stimulant of heart and circulation as well as respiration. Also used as a sedative and nervous depressant in convulsions, hysteria, epilepsy, chorea. Topically used as a rubefacient and mild analgesic.

Key application: Externally in catarrhal diseases of the respiratory tract and muscular rheumatism; internally in hypotonic circulatory regulation disorders, Catarrhal diseases of the respiratory tract. (German Commission E.)

The plant contains a volatile oil comprising camphor, safrole, linalool, eugenol and terpeneol. It also contains lignans (including secoisosolari- ciresinol dimethyl ether and kusunoki- ol). Safrole is thought to be carcinogenic.

The leaf oil is a natural source of linalool (94.9%); also contained cit- ronellal (2.4%).

Camphor in concentration of 500 mcg/ml completely inhibits the growth of vibro parahaemolyticus, one of the causative agents of diarrhoea and dysentery. Ethanolic extract (50%) of fruits show antibacterial activity against several Gram-positive and Gram-negative bacteria. The essential oil from the plant possesses antifungal activity against many fungi. Camphor is toxic at 2-20 g.

Dosage: Concentrate—125-375 mg (CCRAS.)... cinnamomum camphora

Indian Bdellium

Commiphora mukul

Burseraceae

San: Gugulu, Mahisaksah, Koushikaha, Devadhupa

Hin: Gugal Mal:Gulgulu Tam,

Tel: Gukkulu

Kan: Guggul

Ben: Guggul

Importance: Indian bdellium is a small, armed, deciduous tree from the bark of which gets an aromatic gum resin, the ‘Guggul’ of commerce. It is a versatile indigenous drug claimed by ayurvedists to be highly effective in the treatment of rheumatism, obesity, neurological and urinary disorders, tonsillitis, arthritis and a few other diseases. The fumes from burning guggul are recommended in hay- fever, chronic bronchitis and phytises.

The price of guggulu gum has increased ten fold in ten years or so, indicating the increase in its use as well as decrease in natural plant stand. It has been listed as a threatened plant by Botanical Survey of India (Dalal, 1995) and is included in the Red Data Book (IUCN) and over exploited species in the country (Billare,1989).

Distribution: The center of origin of Commiphora spp. is believed to be Africa and Asia. It is a widely adapted plant well distributed in arid regions of Africa (Somalia, Kenya and Ethiopia in north east and Madagascar, Zimbabwe, Botswana, Zaire in south west Africa), Arabian peninsula (Yemen, Saudi Arabia and Oman). Different species of Commiphora are distributed in Rajasthan, Gujarat, Maharashtra and Karnataka states of India and Sind and Baluchistan provinces of Pakistan (Tajuddin et al, 1994). In India, the main commercial source of gum guggul is Rajasthan and Gujarat.

Botany: The genus Commiphora of family Burseraceae comprises about 185 species. Most of them occur in Africa, Saudi Arabia and adjoining countries. In India only four species have been reported. They are C. mukul(Hook. ex Stocks) Engl. syn. Balsamodendron mukul (Hook. ex Stocks), C. wightii (Arnott) Bhandari, C.stocksiana Engl., C. berryi and C.agallocha Engl.

In early studies about the flora of India, the ‘guggul’ plant was known as Commiphora mukul(Hook. ex Stocks) Engl. or Balsamodendron mukul (Hook. ex Stocks). It was renamed as C. roxburghii by Santapau in 1962. According to Bhandari the correct Latin name of the species is C. wightii(Arnott) Bhandari, since the specific name ‘wightii’ was published in 1839, prior to ‘roxburghi’ in 1848 (Dalal and Patel, 1995).

C. mukul is a small tree upto 3-4m height with spinescent branching. Stem is brownish or pale yellow with ash colored bark peeling off in flakes. Young parts are glandular and pubescent. Leaves are alternate, 1-3 foliate, obovate, leathery and serrate (sometimes only towards the apex). Lateral leaflets when present only less than half the size of the terminal ones. Flowers small, brownish red, with short pedicel seen in fascicles of 2-3. Calyx campanulate, glandular, hairy and 4-5 lobed. Corolla with brownish red, broadly linear petals reflexed at apex. Stamens 8-10, alternatively long and short. Ovary oblong, ovoid and stigma bifid. Fruit is a drupe and red when ripe, ovate in shape with 2-3 celled stones. The chromosome number 2n= 26 (Warrier et al, 1994; Tajuddin et al, 1994).

Agrotechnology: Guggal being a plant of arid zone thrives well in arid- subtropical to tropical climate.

The rainfall may average between 100mm and 500mm while air temperature may vary between 40 C in summer and 3 C during winter. Maximum relative humidity prevails during rainy season (83% in the morning and 48% in the evening).Wind velocity remains between 20-25 km/hour during the year is good. Though they prefer hard gypseous soil, they are found over sandy to silt loam soils, poor in organic matter but rich in several other minerals in arid tracks of western India (Tajuddin et al, 1994).

Plants are propagated both by vegetatively and seeds. Plants are best raised from stem cuttings from the semi woody (old) branch. For this purpose one metre long woody stem of 10mm thickness is selected and the cut end is treated with IBA or NAA and planted in a well manured nursery bed during June-July months; the beds should be given light irrigation periodically. The cuttings initiate sprouting in 10-15 days and grow into good green sprout in 10-12 months. These rooted plants are suitable for planting in the fields during the next rainy season. The cuttings give 80-94% sprouting usually. Air layering has also been successfully attempted and protocol for meristem culture is available in literature. Seed germination is very poor (5%) but seedling produce healthier plants which withstand high velocity winds.

The rooted cuttings are planted in a well laid-out fields during rainy season. Pits of size 0.5m cube are dug out at 3-4 m spacing in rows and given FYM and filler soil of the pit is treated with BHC (10%) or aldrin (5%) to protect the new plants from white ants damage. Fertilizer trials have shown little response except due to low level of N fertilization. Removal of side branches and low level of irrigation supports a good growth of these plants. The plantation does not require much weeding and hoeing. But the soil around the bushes be pulverised twice in a year to increase their growth and given urea or ammonium sulphate at 25- 50g per bush at a time and irrigated. Dalal et al (1989) reported that cercospora leaf spot was noticed on all the cultures. Bacterial leaf blight was also noticed to attack the cultures. A leaf eating caterpillar (Euproctis lanata Walker) attack guggal, though not seriously. White fly (Bemisia tabaci) is observed to suck sap of leaves and such leaves become yellowish and eventually drop. These can be effectively controlled by using suitable insecticide.

Stem or branch having maximum diameter of about 5cm at place of incision, irrespective of age is tapped. The necrotic patch on the bark is peeled off with a sharp knife and Bordeaux paste is applied to the exposed (peeled off) surface of the stem or branch. A prick chisel of about 3cm width is used to make bark- deep incisions and while incising the bark, the chisel is held at an acute angle so that scooped suspension present on the body of the chisel flows towards the blade of the chisel and a small quantity of suspension flows inside the incised bark. If tapping is successful, gum exudation ensures after about 15-20 days from the date of incision and continues for nearly 30-45 days. The exuded gum slides down the stem or branch, and eventually drops on the ground and gets soiled. A piece of polythene sheet can be pouched around the place of incision to collect gum. Alternatively, a polythene sheet can be spread on the ground to collect exuded gum. A maximum of about 500g of gum has been obtained from a plant (Dalal, 1995).

Post harvest technology: The best grade of guggul is collected from thick branches of tree. These lumps of guggul are translucent. Second grade guggul is usually mixed with bark, sand and is dull coloured guggul. Third grade guggul is usually collected from the ground which is mixed with sand, stones and other foreign matter. The final grading is done after getting cleansed material. Inferior grades are improved by sprinkling castor oil over the heaps of the guggul which impart it a shining appearance (Tajuddin et al, 1994).

Properties and activity: The gum resin contains guggul sterons Z and E, guggul sterols I-V, two diterpenoids- a terpene hydrocarbon named cembreneA and a diterpene alcohol- mukulol, -camphrone and cembrene, long chain aliphatic tetrols- octadecan-1,2,3,4-tetrol, eicosan-1,2,3,4-tetrol and nonadecan-1,2,3,4-tetrol. Major components from essential oil of gum resin are myrcene and dimyrcene. Plant without leaves, flowers and fruits contains myricyl alcohol, -sitosterol and fifteen aminoacids. Flowers contain quercetin and its glycosides as major flavonoid components, other constituents being ellagic acid and pelargonidin glucoside (Patil et al, 1972; Purushothaman and Chandrasekharan, 1976).

The gum resin is bitter, acrid, astringent, thermogenic, aromatic, expectorant, digestive, anthelmintic, antiinflammatory, anodyne, antiseptic, demulcent, carminative, emmenagogue, haematinic, diuretic, lithontriptic, rejuvenating and general tonic. Guggulipid is hypocholesteremic (Husain et al, 1992; Warrier et al, 1994).... indian bdellium

Ipomoea Bona-nox

Linn.

Synonym: I. alba Linn. Calonyction bona-nox Bojer. C. aculeatum (Linn.) House.

Family: Convolvulaceae.

Habitat: Throughout India.

English: Moon Flower.

Ayurvedic: Chandrakaanti, Gul- chaandani, Dudhiaa Kalami.

Siddha/Tamil: Naganamukkori.

Folk: Chaandani, Dudhiaa Kalami.

Action: Root bark—purgative. Leaves—used in filariasis.

The plant contains pentasaccharide glucoside of ethyl-ll-hydroxy hexade- canoate. The seeds contain alkaloids, ipomine, isoipomine, methoxyipo- mine, dimethoxyipomine, ipalkidini- um, ipalbidine and ipalbine.... ipomoea bona-nox

Kaempferia Galanga

Linn.

Family: Zingiberaceae.

Habitat: Throughout the plains of India, cultivated in gardens.

Ayurvedic: Sugandha-vachaa, Chandramuula, Chandramuulikaa. (In Kerala, used as Karchura and Shathi.) (Kapurakachari is a different drug, equated with Hedychium spicatum.)

Siddha/Tamil: Kachoram.

Action: Tuber—stimulant, carminative, expectorant, diuretic used for respiratory ailments like cough, bronchitis and asthma.

The essential oil from rhizomes contain n-pentadecane, ethyl-p-methoxy cinnamate, ethyl cinnamate, carene, camphene, borneol, p-methoxysty- rene, p-methoxy cinnamate, p-meth- oxy-trans-cinnamic acid and cin namaldehyde. Insecticidal activity of the oil is attributed to ethyl cinna- mates. Ethyl-p-methoxy-cinnamate shows monoamine oxidase inhibitor activity and a cytotoxic principle (the rhizomes exhibit cytotoxic activity).

Leaves and flowers exhibit antiphlogistic and vitamin P activity. Ethyl-p- methoxy-trans cinnamate is the main compound in the root.... kaempferia galanga

Lepidium Sativum

Linn.

Family: Curciferace, Brassicaceae.

Habitat: Native to West Asia; cultivated throughout India as a salad plant.

English: Garden Cress, Water Cress.

Ayurvedic: Chandrashuura, Chan- drikaa, Vaas-pushpaa, Pashume- hankaarikaa, Nandini, Suvaasaraa, Aashaalim.

Unani: Habb-ul-rashaad, Tukh-e- Taratezak, Haalim, Sipandaan.

Siddha/Tamil: Alivirai.

Action: Used in asthma, bronchial affections and bleeding piles. Seeds—lactagogue, diuretic, and emmenagogue. Used for treating skin disorders, fever, amoebic dysentery and asthma. Leaf— stimulant, antiscorbutic, diuretic. Roots—used in secondary syphilis and in tenesmus.

The Ayurvedic Pharmacopoeia of India recommends the use of dried seeds, in powder form, in gout.

The seeds are a good source of iron, but its bioavailability is poor (5.4% of total iron). They are used for rapid healing ofbone fractures. The ethano- lic extract of seeds significantly increased collagen synthesis and its deposition at bone fracture portion in the treated rats. The tensile strength of the broken tibiae also increased.

The seeds contain an alkaloid (0.19%), glucotropaeolin, sinapin (cho- line ester of sinapic acid), sinapic acid, mucilaginous matter (5%) and uric acid (0.108 g/kg). The seed oil exhibits pronounced oestrogenic activity.

The seed mucilage allays the irritation of the mucous membrane of intestines in dysentery and diarrhoea. It consists of a mixture of cellulose (18.3%) and uronic acid-containing polysaccharides; acid hydrolysis yield L-arabinose, D-galactose, L-rhamnose, D-glacturonic acid and D-glucose.

The plant contains pantothenic acid, pyridoxin and rutin. Ethanolic extract of the plant showed antiviral activity against rinderpest virus.

Dosage: Seed—3-6 g powder. (API, Vol. I.)... lepidium sativum

Mallotus Philippensis

Muell.-Arg.

Family: Euphorbiaceae.

Habitat: Throughout tropical regions of India.

English: Kamala tree, Monkey Face tree.

Ayurvedic: Kampillaka, Kampilla, Karkash, Raktaanga, Rechan, Chandra.

Unani: Kamilla, Kambilaa.

Siddha/Tamil: Kapli, Kalupatti.

Action: Gland and hair of fruit— purgative, anthelmintic, styptic. Used for the treatment of tapeworm infestation; in scabies, ringworm, herpes. Fruit—hypoglycaemic, spasmolytic, antibacterial.

Capsule hair and glands gave phlo- roglucinol derivatives; rottlerin, isorot- tlerin, iso-allorottlerin (the "red compound") and methylene-b¿s-methyl- phloroacetophenone (the "yellow compound"). The red powder, obtained from capsules, containing largely resinous matter, had lithotropic effect in rats, comparable to drugs used commonly against urinary calculi. Two more compounds designated as kama- lins 1 and 2 have been isolated.

The stem bark contains kamaladiol- 3-acetate and friedelin.

Dosage: Glands and hairs of the fruit—0.5-1.0 g powder. (API, Vol.I.)... mallotus philippensis

Rhynchosia Minima

(L.) DC.

Family: Papilionaceae.

Habitat: All over plains and in the Himalayas up to 1,200 m.

Folk: Raan-ghevaraa (smaller var.) (Maharashtra); Jhinki, Kammervel (Gujarat); Chittavarai (Tamil Nadu).

Action: Leaves—abortifacient. Seeds—bitter, toxic.

The leaves afforded isovitexin and apigenin derivatives.

Aerial parts gave steroidal glyco- sides, along with ergosterol peroxide, stigmasterol and lupeol; bergapten, isopimpinellin, umbelliferone and beta-sitosterol have also been isolated.

The seed coat and pericarp contained gallic and protocatechuic acid, prodelphinmidine and hydroquinone diacetate and C-glycosyl flavones.

The extract of seeds shows agglutinating activity with certain type of human red blood cells.

R. bracteata Benth. ex Baker (upper Gangetic plains) and R. jacobii Chandra & Shetty (Tirunelveli, Tamil Nadu) contain vitexin, isovitexin, orientin, iso-orientin and apigenin derivatives.... rhynchosia minima

Serpentwood

Rauvolfia serpentina

Apocynaceae

San: Sarpagandha

Hin: Chandrabhaga

Mal: Sarpagandhi, Amalpori

Tam: Chivan amelpodi

Kan: Sutranbhi

Tel: Patalagandhi

Introduction: Serpentwood is an erect, evergreen , perennial undershrub whose medicinal use has been known since 3000 years. Its dried root is the economical part which contains a number of alkaloids of which reserpine, rescinnamine, deserpidine, ajamalacine, ajmaline, neoajmalin, serpentine, -yohimbine are pharmacologically important. The root is a sedative and is used to control high blood pressure and certain forms of insanity. In Ayurveda it is also used for the treatment of insomnia, epilepsy, asthma, acute stomach ache and painful delivery. It is used in snake-bite, insect stings, and mental disorders. It is popular as “Madman’s medicine” among tribals. ‘Serpumsil’ tablet for high blood pressure is prepared from Rauvolfia roots. Reserpine is a potent hypotensive and tranquillizer but its prolonged usage stimulates prolactine release and causes breast cancer. The juice of the leaves is used as a remedy for the removal of opacities of the cornea.

Distribution: Rauvolfia serpentina is native to India. Several species of Rauvolfia are observed growing under varying edaphoclimatic conditions in the humid tropics of India, Nepal, Burma, Thailand, Bangladesh, Indonesia , Cambodia, Philippines and Sri Lanka. In India, it is cultivated in the states of Uttar Pradesh, Bihar, Tamil Nadu, Orissa, Kerala, Assam, West Bengal and Madhya Pradesh (Dutta and Virmani, 1964). Thailand is the chief exporter of Rauvolfia alkaloids followed by Zaire, Bangladesh, Sri Lanka, Indonesia and Nepal. In India, it has become an endangered species and hence the Government has prohibited the exploitation of wild growing plants in forest and its export since 1969.

Botany: Plumier in 1703 assigned the name Rauvolfia to the genus in honour of a German physcian -Leonhart Rauvolf of Augsburg. The genus Rauvolfia of Apocynaceae family comprises over 170 species distributed in the tropical and subtropical parts of the world including 5 species native to India. The common species of the genus Rauvolfia and their habitat as reported by Trivedi (1995) are given below.

R. serpentina Benth. ex Kurz.(Indian serpentwood) - India ,Bangladesh, Burma, Sri Lanka, Malaya, Indonesia

R. vomitoria Afz. (African serpentwood) - West Africa, Zaire, Rwanda, Tanzania R. canescens Linn. syn. R. tetraphylla (American serpentwood) - America, India R. mombasina - East Africa , Kenya, Mozambique

R. beddomei - Western ghats and hilly tracts of Kerala

R. densiflora - Maymyo, India

R. microcarpa - Thandaung

R. verticillata syn. R. chinensis - Hemsl

R. peguana - Rangoon-Burma hills

R. caffra - Nigeria, Zaire, South Africa

R. riularis - Nmai valley

R. obscura - Nigeria, Zaire

R. serpentina is an erect perennial shrub generally 15-45 cm high, but growing upto 90cm under cultivation. Roots nearly verticle, tapering up to 15 cm thick at the crown and long giving a serpent-like appearance, occasionally branched or tortuous developing small fibrous roots. Roots greenish-yellow externally and pale yellow inside, extremely bitter in taste. Leaves born in whorls of 3-4 elliptic-lanceolate or obovate, pointed. Flowers numerous borne on terminal or axillary cymose inflorscence. Corolla tubular, 5-lobed, 1-3 cm long, whitish-pink in colour. Stamens 5, epipetalous. Carpels 2, connate, style filiform with large bifid stigma. Fruit is a drupe, obliquely ovoid and purplish black in colour at maturity with stone containing 1-2 ovoid wrinkled seeds. The plant is cross-pollinated, mainly due to the protogynous flowers (Sulochana ,1959).

Agrotechnology: Among the different species of Rauvolfia, R. serpentina is preferred for cultivation because of higher reserpine content in the root. Though it grows in tropical and subtropical areas which are free from frost, tropical humid climate is most ideal. Its common habitats receive an annual rain fall of 1500-3500 mm and the annual mean temperature is 10-38 C. It grows up to an elevation of 1300-1400m from msl. It can be grown in open as well as under partial shade conditions. It grows on a wide range of soils. Medium to deep well drained fertile soils and clay-loam to silt-loam soils rich in organic matter are suitable for its cultivation. It requires slightly acidic to neutral soils for good growth.

The plant can be propagated vegetatively by root cuttings, stem cuttings or root stumps and by seeds. Seed propagation is the best method for raising commercial plantation. Seed germination is very poor and variable from 10-74%. Seeds collected during September to November give good results. It is desirable to use fresh seeds and to sock in 10% sodium chloride solution. Those seeds which sink to the bottom should only be used. Seeds are treated with ceresan or captan before planting in nursery to avoid damping off. Seed rate is 5-6 kg/ha. Nursery beds are prepared in shade, well rotten FYM is applied at 1kg/m2 and seeds are dibbled 6-7cm apart in May-June and irrigated.

Two months old seedlings with 4-6 leaves are transplanted at 45-60 x 30 cm spacing in July -August in the main field. Alternatively, rooted cuttings of 2.5-5cm long roots or 12-20cm long woody stems can also be used for transplanting. Hormone (Seradix) treatment increases rooting. In the main field 10-15 t/ha of FYM is applied basally. Fertilisers are applied at 40:30:30kg N: P2O5 :K2O/ha every year. N is applied in 2-3 splits. Monthly irrigation increases the yield. The nursery and the main field should be kept weed free by frequent weeding and hoeing. In certain regions intercroping of soybean, brinjal, cabbage, okra or chilly is followed in Rauvolfia crop.

Pests like root grubs (Anomala polita), moth (Deilephila nerii), caterpillar (Glyophodes vertumnalis), black bugs and weevils are observed on the crop, but the crop damage is not serious. The common diseases reported are leaf spot (Cercospora rauvolfiae, Corynespora cassiicola), leaf blotch (Cercospora serpentina), leaf blight (Alternaria tenuis), anthracnose (Colletotrichum gloeosporioides), die back (Colletotrichum dematrium), powdery mildew (Leviellula taurica), wilt (Fusarium oxysporum), root-knot (Meloidogyne sp.), mosaic and bunchy top virus diseases. Field sanitation, pruning and burning of diseased parts and repeated spraying of 0.2% Dithane Z-78 or Dithane M-45 are recommended for controlling various fungal diseases. Rauvolfia is harvested after 2-3 years of growth. The optimum time of harvest is in November -December when the plants shed leaves, become dormant and the roots contain maximum alkaloid content. Harvesting is done by digging up the roots by deeply penetrating implements (Guniyal et al, 1988).

Postharvest technology: The roots are cleaned washed cut into 12-15cm pieces and dried to 8-10% moisture.

The dried roots are stored in polythene lined gunny bags in cool dry place to protect it from mould. The yield is 1.5-2.5 t/ha of dry roots. The root bark constitutes 40-45% of the total weight of root and contributes 90% of the total alkaloids yield.

Properties and activity: Rauvolfia root is bitter, acrid, laxative, anthelmintic, thermogenic, diuretic and sedative. Over 200 alkaloids have been isolated from the plant. Rauvolfia serpentina root contains 1.4-3% alkaloids. The alkaloids are classsified into 3 groups, viz, reserpine, ajmaline and serpentine groups. Reserpine group comprising reserpine, rescinnamine, deserpine etc act as hypotensive, sedative and tranquillising agent. Overdose may cause diarrhoea, bradycardia and drowsiness. Ajmaline, ajmalicine, ajmalinine, iso-ajmaline etc of the ajmaline group stimulate central nervous system, respiration and intestinal movement with slight hypotensive activity. Serpentine group comprising serpentine, sepentinine, alstonine etc is mostly antihypertensive. (Husain,1993; Trivedi, 1995; Iyengar, 1985).... serpentwood



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