Edta Health Dictionary

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Edta: From 1 Different Sources

Ethylenediamine tetra-acetic acid is used to treat poisoning with metals such as lead and strontium. One of the CHELATING AGENTS, EDTA is used in the form of sodium or calcium salts. The stable chelate compounds resulting from the treatment are excreted in the urine.
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Lead Poisoning

Lead and lead compounds are used in a variety of products including petrol additives (in the UK, lead-free petrol is now mandatory), piping (lead water pipes were once a common source of poisoning), weights, professional paints, dyes, ceramics, ammunition, homeopathic remedies, and ethnic cosmetic preparations. Lead compounds are toxic by ingestion, by inhalation and, rarely, by skin exposures. Metallic lead, if ingested, is absorbed if it remains in the gut. The absorption is greater in children, who may ingest lead from the paint on old cots

– although lead-containing paints are no longer used for items that children may be in contact with.

Acute poisonings are rare. Clinical features include metallic taste, abdominal pain, vomiting, diarrhoea, ANOREXIA, fatigue, muscle weakness and SHOCK. Neurological effects may include headache, drowsiness, CONVULSIONS and COMA. Inhalation results in severe respiratory-tract irritation and systemic symptoms as above.

Chronic poisonings cause gastrointestinal disturbances and constipation. Other effects are ANAEMIA, weakness, pallor, anorexia, insomnia, renal HYPERTENSION and mental fatigue. There may be a bluish ‘lead line’ on the gums, although this is rarely seen. Neuromuscular dysfunction may result in motor weakness and paralysis of the extensor muscles of the wrist and ankles. ENCEPHALOPATHY and nephropathy are severe effects. Chronic low-level exposures in children are linked with reduced intelligence and behavioural and learning disorders.

Treatment Management of patients who have been poisoned is supportive, with removal from source, gastric decontamination if required, and X-RAYS to monitor the passage of metallic lead through the gut if ingested. It is essential to ensure adequate hydration and renal function. Concentrations of lead in the blood should be monitored; where these are found to be toxic, chelation therapy should be started. Several CHELATING AGENTS are now available, such as DMSA (Meso-2,3dimercaptosuccinic acid), sodium calcium edetate (see EDTA) and PENICILLAMINE. (See also POISONS.)... lead poisoning

Ndga

Nordihydroguaiaretic acid, a substance found in abundance in the oleoresins of Larrea (Chaparral) and the Guaiacum genus (Lignum Vitae). It is strongly antioxidant to lipids and is antifungal, antimicrobial and antibacterial. Both plants contain a constellation of related compounds and do not have the potential kidney toxicity found in pure NDGA...and the reason it is no longer used as an EDTA-type edible oil stabilizer in food manufacturing.... ndga

Chelation

From the Greek ‘chele’ meaning to claw or grip. Deposits of cholesterol and by-products of free radical activity may cause arteries to become brittle and block circulation. Chelation offers an internal ‘house cleaning’ whereby such deposits and metals are freed into the circulation for elimination from the body.

Chelation is increasingly used as an alternative to by-pass surgery for coronary disease, significantly improving the coronary circulation. Reportedly of value for improved kidney function, decreased insulin requirement for diabetes, to reduce prostate obstruction, restore near-normal breathing pattern in emphysema and to bring relief in arthritis. Specific herbs act as bonding agents to metals in blood vessel plague prior to expulsion via the kidneys and bowel.

Conventional medical chelation therapy consists of an intravenous drip of a synthetic amino acid, EDTA (ethylene diamine tetra-acetic acid) which leeches from the tissues toxic metals (lead, mercury etc) prior to elimination. Cholesterol and fats are dissolved and metabolised by the liver, and metals are excreted by the kidneys.

Supportive aid to primary treatment. Combine tinctures: Hawthorn 2; Lily of the Valley 1; Capsicum quarter. Dose: 15-60 drops in water thrice daily.

Saponin-containing herbs, by their detergent action act as binding agents to leech metals, plague etc from blood vessels and the intestinal canal.

Diet. Guar gum preparations. Low salt. Fish oils or oily fish.

Supplements. Vitamins A, C, D (Cod Liver oil), B-complex, especially Vitamin B12, biotin, PABA, chromium, selenium, zinc, methionine, superoxide dismutase, magnesium.

Information. The Arterial Disease Clinic: tel: 0942 676617. ... chelation

Band Keratopathy

the deposition of calcium in the superficial layers of the cornea, usually as a horizontal band starting peripherally and moving centrally. It is associated with chronic eye disease, e.g. chronic *uveitis, particularly juvenile chronic uveitis. It is treated by application of EDTA (see edetate) or with an *excimer laser.... band keratopathy

Chelating Agent

a chemical compound whose molecules form complexes by binding metal ions. Some chelating agents, including *desferrioxamine and *penicillamine, are drugs used to treat metal poisoning: the metal is bound to the drug and excreted safely. Chelating agents often form the active centres of enzymes. The chelating agent ethylenediaminetetraacetic acid (EDTA) is used in dentistry to remove the *smear layer before root canal filling.... chelating agent

Edetate

n. a salt of ethylenediaminetetraacetic acid (EDTA), which is used as a *chelating agent in the treatment of poisoning. Dicobalt edetate is an antidote to cyanide, administered as soon as possible after poisoning. Sodium calcium edetate is used to treat poisoning by heavy metals, especially lead.... edetate

Edrophonium

n. an *anticholinesterase drug that is used after surgery to reverse the effects of nondepolarizing *muscle relaxants and in a test for diagnosis of *myasthenia gravis. Side-effects can include nausea and vomiting, increased saliva flow, diarrhoea, and stomach pains.

EDTA (ethylenediaminetetraacetic acid) see edetate.... edrophonium

Smear Layer

a layer of microcrystalline and organic particle debris that remains on the hard tissues of the teeth whenever they are cut. It may be important in assisting or preventing the penetration of bacteria into the dentinal tubules. The success of root canal treatment depends on the complete removal of the smear layer with a *chelating agent such as EDTA, but its presence may be useful in restorative dentistry.... smear layer

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