Fibrosing alveolitis Health Dictionary

Fibrosing Alveolitis: From 2 Different Sources


Inflammation and thickening of the walls of the alveoli in the lungs (see alveolus, pulmonary) that results in scarring of lung tissue (see interstitial pulmonary fibrosis). Fibrosing alveolitis most commonly occurs in people over 60 and is more common in men.

In some cases, fibrosing alveolitis is due to an autoimmune disorder and may be associated with conditions such as rheumatoid arthritis or systemic lupus erethematosus. Other possible causes include radiotherapy of the organs in the chest and anticancer drug treatment. In many cases, however, the cause is unknown, and the condition is then known as idiopathic pulmonary fibrosis.

Symptoms of fibrosing alveolitis include shortness of breath, a persistent dry cough, and joint pains.

Treatment of the condition involves corticosteroid drugs combined with other immunosuppressant drugs to slow the progress of lung damage.

Health Source: BMA Medical Dictionary
Author: The British Medical Association

Alveolitis

In?ammation of the alveoli (see ALVEOLUS) of the lungs caused by an allergic reaction. When the in?ammation is caused by infection it is called PNEUMONIA, and when by a chemical or physical agent it is called pneumonitis. It may be associated with systemic sclerosis or RHEUMATOID ARTHRITIS.

Extrinsic allergic alveolitis is the condition induced by the lungs becoming allergic (see ALLERGY) to various factors or substances. It includes BAGASSOSIS, FARMER’S LUNG and BUDGERIGAR-FANCIER’S LUNG, and is characterised by the onset of shortness of breath, tightness of the chest, cough and fever. The onset may be sudden or gradual. Treatment consists of removal of the affected individual from the o?ending material to which he or she has become allergic. CORTICOSTEROIDS give temporary relief.

Fibrosing alveolitis In this disease there is di?use FIBROSIS of the walls of the alveoli of the lungs. This causes loss of lung volume with both forced expiratory volume and vital capacity affected, but the ratio between them remaining normal. The patient complains of cough and progressive DYSPNOEA. Typically the patient will be cyanosed (blue – see CYANOSIS), clubbed (see CLUBBING), and have crackles in the mid- and lower-lung ?elds. Blood gases will reveal HYPOXIA and, in early disease, hypocapnia (de?ciency of carbon dioxide in the blood due to hyperventilation). There is an association with RHEUMATOID ARTHRITIS (about one-eighth of cases), systemic lupus erythematosus (see under LUPUS), and systemic SCLEROSIS. Certain drugs – for example, bleomycin, busulphan and hexamethonium – may also cause this condition, as may high concentrations of oxygen, and inhalation of CADMIUM fumes.... alveolitis




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