Microsporum Health Dictionary

Mould fungi belonging to the genera Microsporum, Trichophyton or Epidermophyton. Cause tinea or ringworm.... dermatophyte

Ringworm, or tinea, is the name given to in?ammatory rashes caused by DERMATOPHYTES of the genera microsporum, epidermophyton and trichophyton. These fungi can infect skin, hair and nails. The important clinical patterns are:

Tinea capitis Usually seen in children in Britain and caused by microsporum species of human or animal (frequently a kitten) origin. Typically, patches of ALOPECIA are seen with broken-o? hair stumps which ?uoresce bright green under an ultraviolet (Wood’s) lamp. In Asia a chronic, scarring alopecia may be caused by a speci?c trichophyton (favus).

Tinea corporis is usually due to trichophyton species and forms ringed (hence ‘ringworm’) patches of redness and scaling on the trunk or limbs.

Tinea pedis (athlete’s foot) is caused by epidermophyton or trichophyton species. Its minor form manifests as itching, scaling or blistering in the lateral toe clefts. More severe forms can be extensive on the sole. Trichophyton rubrum can cause a chronic, dry, scaling in?ammation of the foot, eventually extending into the nails and on to the soles and top of the foot which may persist for years if untreated.

Tinea cruris typically causes a ‘butter?y’ rash on the upper inner thighs in young adult males. It is usually caused by spread from the feet.

Tinea unguium (onychomycosis) Affecting the nails, especially of the toes, T. rubrum is the usual cause and may persist for decades.

Tinea barbae This rash of the face and beard is rare. It may be very in?ammatory and is usually contracted from cattle by farm workers.

Treatment Tinea of the toe clefts and groin will usually respond to an antifungal cream containing terbina?ne or an azole. Tinea capitis, barbae, extensive tinea corporis and all nail infections require oral treatment with terbina?ne or itraconazole (a triazole antifungal agent taken orally and used for candidiasis of the mouth, throat and vulgovaginal area as well as for ringworm) which have largely superseded the earlier treatment with the antiobiotic griseofulvin. (See FUNGAL AND YEAST INFECTIONS.)... ringworm

These infections, also called mycoses (see MYCOSIS), are common and particularly affect the skin or mucosal membranes in, for example, the mouth, anus or vagina. Fungi consist of threadlike hyphae which form tangled masses or mycelia – common mould. In what is called dermatophyte (multicellular fungi) fungal infection of the hair, nails and SKIN, these hyphae invade the KERATIN. This is usually described as ‘RINGWORM’, although no worm is present and the infection does not necessarily occur in rings. PITYRIASIS versicolor and candidosis (monoliasis – see CANDIDA), called thrush when it occurs in the vulva, vagina and mouth, are caused by unicellular fungi which reproduce by budding and are called yeasts. Other fungi, such as ACTINOMYCOSIS, may cause deep systemic infection but this is uncommon, occurring mainly in patients with immunosuppressive disorders or those receiving prolonged treatment with ANTIBIOTICS.

Diagnosis and treatment Any person with isolated, itching, dry and scaling lesions of the skin with no obvious cause – for example, no history of eczema (see DERMATITIS) – should be suspected of having a fungal infection. Such lesions are usually asymmetrical. Skin scrapings or nail clippings should be sent for laboratory analysis. If the lesions have been treated with topical steroids they may appear untypical. Ultraviolet light ?ltered through glass (Wood’s light) will show up microsporum infections, which produce a green-blue ?uorescence.

Fungal infections used to be treated quite e?ectively with benzoic-acid compound ointment; it has now been superseded by new IMIDAZOLES preparations, such as CLOTRIMAZOLE, MICONAZOLE and terbina?ne creams. The POLYENES, NYSTATIN and AMPHOTERICIN B, are e?ective against yeast infections. If the skin is macerated it can be treated with magenta (Castellani’s) paint or dusting powder to dry it out.

Refractory fungal infection can be treated systematically provided that the diagnosis of the infection has been con?rmed. Terbina?ne, imidazoles and GRISEOFULVIN can all be taken by mouth and are e?ective for yeast infections. (Griseofulvin should not be taken in pregnancy or by people with liver failure or porphyria.) (See also FUNGUS; MICROBIOLOGY.)... fungal and yeast infections

Linn.

Family: Euphorbiaceae.

Habitat: Native to South America. Naturalized in various parts of India.

English: Coral plant, Physic Nut.

Ayurvedic: Brihat-Danti (bigger var. of Danti, also equated with Baliospermum montanum).

Folk: Danti (var.).

Action: Seeds—purgative, emetic. Fruits—poisonous. Leaves—used for scabies. Latex—applied to wounds and ulcers.

The latex from the plant showed antibacterial activity against Staphylococ- cus aureus. It contains immunologi- cally active acylphloroglucinols, mul- tifidol, phloroglucinol and multifidol beta-D-glucopyranoside. The latex also contains an immunologically active, cyclic decapeptide, labaditin.

J. panduraefolia Andr. (native to America), widely grown in Indian gardens, is known as Fiddle-leaved Jat- ropha. The latex from the plant shows fungitoxic activity against ringworm fungus, Microsporum gypseum.... jatropha multifida

ultraviolet light filtered through a nickel oxide prism, which causes fluorescence in skin and hair affected by some fungal and bacterial infections and is therefore useful in diagnosis. For example, *erythrasma fluoresces coral pink, while scalp ringworm caused by Microsporum species fluoresces green. [R. W. Wood (1868–1955), US physician]... wood’s light