Organophosphorus Health Dictionary

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Organophosphorus: From 1 Different Sources

Organophosphorus insecticides act by inhibiting the action of cholinesterase (see ACETYLCHOLINE). For this reason they are also toxic to humans and must therefore be handled with great care. The most widely used are PARATHION and MALATHION. Organophosphorus has also been used to make nerve gases (see BIOLOGICAL WARFARE).

Treatment After contamination with insecticides, decontaminate (remove clothes, wash skin). Those treating should wear gloves, mask, apron and goggles. For symptoms give 2 mg of ATROPINE IV every 30 minutes until full atropinisation (dry mouth, pulse >70). Up to three days’ treatment may be needed. Severe poisoning may require pralidoxine mysalate: available from designated centres, this drug should be given intravenously within 24 hours of exposure.

Health Source: Medical Dictionary
Author: Health Dictionary

Malathion

Organophosphorus insecticide which is a preferred scabicide and pediculocide; applied externally; resistance is rare.... malathion

Neuritis

In?ammation affecting a nerve or nerves which may be localised to one part of the body – as, for instance, in SCIATICA – or which may be general, being then known as multiple neuritis, or POLYNEURITIS. Owing to the fact that the most peripheral parts of the nerves are usually affected in the latter condition (i.e. the ?ne subdivisions in the substance of the muscles), it is also known as peripheral neuritis.

Causes In cases of localised neuritis, the ?brous sheath of the nerve is usually at fault, the actual nerve-?bres being only secondarily affected. This condition may be due to in?ammation spreading into the nerve from surrounding tissues; to cold; or to long-continued irritation by pressure on the nerve. The symptoms produced vary according to the function of the nerve, in the case of sensory nerves being usually neuralgic pain (see NEURALGIA), and in the case of motor nerves some degree of paralysis in the muscles to which the nerves pass.

In polyneuritis, usually due to some general or constitutional cause, the nerve-?bres themselves in the small nerves degenerate and break down. The condition is protracted because, for recovery to occur, the growth of new nerve-?bres from the healthy part of the nerve has to take place. The cause of polyneuritis may be infection by a virus – for example, HERPES ZOSTER – or a bacterium, as in LEPROSY. Neuritis may also be the result of agents such as alcohol, lead or products from industrial or agricultural activities. ORGANOPHOSPHORUS insecticides are believed by some to be a factor in neuritis and other neurological conditions.... neuritis

Parathion

One of the ORGANOPHOSPHORUS insecticides. It is highly toxic to humans and must therefore be handled with the utmost care.... parathion

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