Gene therapy is currently used to treat disorders caused by a fault in a single recessive gene, when the defect can remedied by introducing a normal ALLELE. Treating disorders caused by dominant genes is more complicated. CYSTIC FIBROSIS is an example of a disease caused by a recessive gene, and clinical trials are taking place on the e?ectiveness of using LIPOSOMES to introduce the normal gene into the lungs of someone with the disorder. Trials are also underway to test the e?ectiveness of introducing tumour-suppressing genes into cancer cells to check their spread.
Gene therapy was ?rst used in 1990 to treat an American patient. Eleven European medical research councils (including the UK’s) recommended in 1988 that gene therapy should be restricted to correcting disease or defects, and that it should be limited to somatic cells. Interventions in germ-line cells (the sperm and egg) to e?ect changes that would be inherited, though technically feasible, is not allowed (see CLONING; HUMAN GENOME).... gene therapy
A lack of oestrogen induces hot flushes, night sweats, thinning of the bones (osteoporosis) with possible fractures, and a wide range of physical and emotional disorders.
HRT also prevents the increased frequency of coronary disease which may follow the menopause. With oestrogen only, HRT appears to increase the incidence of cancer of the uterine body. Use of oestrogen and progestogen avoids this.
HRT is available as a tablet, transdermal patch, implant or topical cream. Most women notice temporary improvement in their appearance and hot flushes as long as treatment is continued. HRT is not prescribed by the herbal practitioner. Soya and Hops are a mild alternative.
Side-effects of such treatment include blood pressure rise, weight gain and periods probably continue with a monthly bleed. Elderly women taking HRT for osteoporosis may develop bleeding problems, the risk of blood clot and gall bladder diseases.
Helonias has proved a useful alternative, effective in eliminating excess fluids, reducing hot flushes, and relieving that bloated feeling, thus helping the older woman to live a normal life.
Damiana. 1 heaped teaspoon leaves to each cup boiling water; infuse 5-10 minutes; strain. 1 cup 2-3 times daily for 3-6 weeks.
Sarsaparilla. 1oz (30g) root in 1 pint (500ml) water; simmer gently 20 minutes; strain. 1 cup 2-3 times daily for 3-6 weeks.
Supplementation. Daily. Vitamin E, 400iu. Vitamin B-complex (high potency). Evening Primrose oil capsules, 500mg morning and evening. Dolomite, for Calcium and Magnesium, 2 tablets morning and evening.
Note: An extensive study of breast cancer risks with HRT revealed a positive link between the risk of cancer and length of use. Risk of the disease increased with all types of women using HRT with every year of use. Pre-menstrual women were more than twice at risk. It would appear that oestrogens cannot be taken without risk. (Centre for Disease Control, Atlanta, USA) See: OESTROGENS. ... hormone replacement therapy (hrt)
Respiratory distress syndrome is a complication of SHOCK, systemic SEPSIS and viral respiratory infections. It was ?rst described in 1967, and – despite advances with assisted ventilation
– remains a serious disease with a mortality of more than 50 per cent. The maintenance of adequate circulating blood volume, peripheral PERFUSION, acid-base balance and arterial oxygenation is important, and assisted ventilation should be instituted early.
In newborns the mechanism is diferent, being provoked by an inability of the lungs to manufacture SURFACTANT.... respiratory distress syndrome
The exact trigger is unknown, but it is thought that, whatever the stimulus, chemical mediators produced by cells of the immune system or elsewhere in the body spread and sustain an in?ammatory reaction. Cascade mechanisms with multiple interactions are provoked. CYTOTOXIC substances (which damage or kill cells) such as oxygen-free radicals and PROTEASE damage the alveolar capillary membranes (see ALVEOLUS). Once this happens, protein-rich ?uid leaks into the alveoli and interstitial spaces. SURFACTANT is also lost. This impairs the exchange of oxygen and carbon dioxide in the lungs and gives rise to the clinical and pathological picture of acute respiratory failure.
The typical patient with ARDS has rapidly worsening hypoxaemia (lack of oxygen in the blood), often requiring mechanical ventilation. There are all the signs of respiratory failure (see TACHYPNOEA; TACHYCARDIA; CYANOSIS), although the chest may be clear apart from a few crackles. Radiographs show bilateral, patchy, peripheral shadowing. Blood gases will show a low PaO2 (concentration of oxygen in arterial blood) and usually a high PaCO2 (concentration of carbon dioxide in arterial blood). The lungs are ‘sti?’ – they are less e?ective because of the loss of surfactant and the PULMONARY OEDEMA.
Causes The causes of ARDS may be broadly divided into the following:... acute respiratory distress syndrome (ards)
Research has shown that cognitive therapy is very e?ective in depression and that it can also help in anxiety, OBSESSIVE COMPULSIVE DISORDER, and EATING DISORDERS such as anorexia and bulimia nervosa. This therapy is also proving useful in helping people cope with HALLUCINATIONS and other symptoms of SCHIZOPHRENIA.... cognitive behaviour therapy
Before treatment, the patient will have been fasted for at least eight hours. After checking for any potential drug ALLERGY or interactions, the patient is given a general anaesthetic and muscle relaxants. Depending on the side of the patient’s dominance, either unilateral (on the side of the non-dominant hemisphere of the BRAIN) or bilateral (if dominance is uncertain,
e.g. in left-handed people) positioning of electrodes is used. Unilateral ECT has the advantage of being associated with less anterograde AMNESIA. When the current passes, the muscles will contract for approximately 10 seconds, with further tonic spasms lasting up to a minute. The patient should then be put in the COMA or recovery position and observed until fully conscious. Up to 12 treatments may be given over a month, improvement usually showing after the third session. Widely used at one time, the treatment is now given only rarely. It can be extremely frightening for patients and relatives and is not recommended for children.... electroconvulsive therapy (ect)
In developed countries ORT is useful in treating gastroenteritis. There are a number of proprietary preparations, often dispensed as ?avoured sachets, including Dioralyte® and Rehydrate®.... oral rehydration therapy (ort)
In 1997 the Royal College of Psychiatrists in the UK produced a comprehensive report which was sceptical about the notion that the awareness of recurrent severe sexual abuse in children could be pushed entirely out of consciousness. The authors did not believe that events could remain inaccessible to conscious memory for decades, allegedly provoking vague non-speci?c symptoms to be recovered during psychotherapy with resolution of the symptoms. Supporting evidence pointed to the lack of any empirical proof that unconscious dissociation of unpleasant memories from conscious awareness occurred to protect the individual. Furthermore, experimental and natural events had shown that false memories, created through suggestion or in?uence, could be implanted. Many individuals who had claimed to have recovered memories of abuse subsequently withdrew and, often, non-speci?c symptoms allegedly linked to suppression worsened rather than improved as therapy to unlock memories proceeded. The conclusion is that recovered memory therapy should be viewed with great caution.... repressed memory therapy
A doctor with knowledge of herbal medicine may prescribe them should he consider them a necessary part of treatment. ... freedom of individual to choose therapy
Basically, the therapy consists of a vegetarian diet with meals of vegetables, fruits and whole grains, fresh or freshly prepared. Drinking water is replaced by hourly, fresh, raw juices of vegetables and fruits. Refined, altered, denatured or enhanced foodstuffs are forbidden. The diet is sodium, chloride, fat and protein restricted. Supplemental potassium, iodine, thyroid and crude liver extract comprise the medical armamentarium. A repeatable choleretic, enemas of a solution of boiled coffee, is administered to lower serum toxin levels. Coffee is a potent enhancer of the carcinogen detoxifying enzyme system, glutathione S-translerase (Wattenburg). The Gerson cancer therapy reduces accumulated tissue sodium and chloride, promoting diuresis. Gerson Therapy Center: Hospital de Baja California, at La Gloria, Mexico
Diet. Lunch and dinner contain ample cooked food, mainly to act as a ‘blotter’ to the daily intake of 5.25 pints fresh raw fruit juices that are the backbone of the therapy. Ingredients of the juices include 41bs raw organic carrots a day, with no harm to the liver. (JAM, May 1991, p5. Beata Bishop on her recovery from metastasised malignant melanoma)
The Gerson therapy is based on the ‘holistic’ philosophy which states that cancer represents a clinical manifestation of an underlying toxic condition. Such condition should receive primary treatment that is lifestyle orientated. The theme is: detoxification through internal cleansing. The diet and supplements are re-inforced by ‘positive thinking’ and supported by meditation and emotional balance. ... gerson cancer therapy
Nicotine products are available in the form of sublingual tablets, chewing gum, skin patches, nasal spray, or inhaler.
Side effects may include nausea, headache, palpitations, cold or flu-like symptoms, hiccups, and vivid dreaming.
Nicotine replacement therapy should be used as part of a complete package of measures, including the determination to succeed.... nicotine replacement therapy
The technique may be used to treat a malignant effusion (a collection of fluid that contains cancerous cells). A needle, sometimes with a catheter attached, is passed through the wall of the abdomen or the chest into the abdominal cavity or pleural cavity (the space around the lungs). As much of the fluid as possible is withdrawn from the cavity before anticancer drugs are injected directly into it. (See also interstitial radiotherapy.)... intracavitary therapy
(See also hyperbaric oxygen treatment.)... oxygen therapy
The amount of fluid necessary depends on age, weight, and the degree of dehydration.
Mild dehydration can usually be treated with oral solutions, which are available as effervescent tablet or powder to be made up at home.
In severe dehydration, or if the patient cannot take fluids by mouth because of nausea or vomiting, an intravenous infusion of saline and/or glucose solution may be given in hospital.... rehydration therapy
Treatment is with ventilation and oxygen for the underlying cause.... respiratory failure
respiratory distress syndrome (RDS; hyaline membrane disease) the condition of a newborn infant in which the lungs are imperfectly expanded. Initial inflation and normal expansion of the lungs requires the presence of a substance (*surfactant) that reduces the surface tension of the air sacs (alveoli) and prevents collapse of the small airways. Without surfactant the airways collapse, leading to inefficient and ‘stiff’ lungs. The condition is most common and serious among preterm infants, in whom surfactant may be deficient. It lasts 5–10 days, with worsening on days 2–3. Breathing is rapid, laboured, and shallow, and microscopic examinations of lung tissue in fatal cases has revealed the presence of *hyalin material in the collapsed air sacs. The condition is treated by careful nursing, intravenous fluids, and oxygen, with or without positive-pressure ventilation (see noninvasive ventilation). Early surfactant replacement therapy has been shown to reduce the severity of RDS and when given prophylactically it has been demonstrated to improve clinical outcome. See also adult respiratory distress syndrome.... respiratory distress