Uric Acid: From 4 Different Sources
A waste product of the breakdown of nucleic acids in body cells. A small amount is also produced by the digestion of foods rich in nucleic acids, such as liver, kidney, and other offal. Most uric acid produced in the body passes to the kidneys, which excrete it in the urine, but some passes into the intestine, where it is broken down into chemicals excreted in the faeces.
When uric acid excretion is disrupted, for example by kidney disease, it may result in hyperuricaemia.
The final end product of certain native or dietary proteins, especially the nucleoproteins found in the nucleus of cells. Unlike the much smaller nitrogenous waste product urea, which is mostly recycled to form many amino acids, uric acid is an unrecyclable metabolite. It is a bent nail that won’t restraighten, and it must be excreted: nucleoprotein to purine to uric acid to the outside in the urine or the sweat. (See GOUT, PURINES.)
A crystalline substance, very slightly soluble in water, of chemical formula, C5N4H4O3. The average daily quantity of uric acid passed by human beings is 0·5–1 gram. It is formed in the LIVER from the breakdown products of proteins and removed by the KIDNEYS from the blood. The amount is increased in the following conditions:
Excessive consumption of meat, combined with sedentary habits.
GOUT.
Diseases in which the white corpuscles of the blood are increased: for example, LEUKAEMIA.
The bi-urate of sodium and urate of ammonium occur in considerable amounts in the URINE during a feverish state or after great exertion, and produce, as the urine cools, a dense pink or yellow sediment. Owing to their insolubility, uric acid and the various urates often produce deposits in the urinary passages, which are known as urinary sand, gravel, or stones according to their size.
a nitrogen-containing organic acid that is the end-product of nucleic acid metabolism and is a component of the urine. Crystals of uric acid are deposited in the joints of people suffering from *gout.
Specifically, the abnormal buildup of acids in the body, classically caused by diabetes or kidney disease. Broadly, the potential caused by increased protein intake or metabolism, coupled with inadequate intake (or loss) of alkali.... acidosis
A colourless, pungent, fuming liquid. Secreted by the parietal cells in the lining of the stomach, it aids in the digestion of the food.... hydrochloric acid
Chemical compounds that are the basic building-blocks of all proteins. Each molecule consists of nitrogenous amino and acidic carboxyl groups of atoms joined to a group of carbon atoms. Polypeptides are formed by amino-acid molecules linking via peptide bonds. Many polypeptides link up in various con?gurations to form protein molecules. In humans, proteins are made up from 20 di?erent amino acids: nine of these are labelled ‘essential’ (or, as is now preferred, ‘indispensable’) amino acids because the body cannot manufacture them and is dependent on the diet for their provision. (See also INDISPENSABLE AMINO ACIDS.)... amino acids
Ascorbic acid, or vitamin C (see APPENDIX 5: VITAMINS), is a simple sugar found in living tissues – its highest concentrations being in the adrenal cortex (see ADRENAL GLANDS) and the eye. Stress and CORTICOTROPIN lead to a loss of ascorbic acid from the adrenal cortex. Fresh fruit and vegetables, particularly blackcurrants, citrus fruits, berries and green vegetables, are the richest dietary sources; it may also be synthetically prepared. Ascorbic acid is easily eliminated from the diet by traditional methods of cooking, being very soluble in water and easily destroyed by heat, alkalis, traces of copper or by an oxidase released by damage to plant tissues. De?ciency may lead to SCURVY, traditionally associated with sailors, among elderly people living alone or in poor communities living at subsistence level. It has been claimed that large doses (1–2 g daily) will prevent the common cold, but few large controlled trials have been carried out and it is inadvisable for people to dose themselves with large quantities of ascorbic acid, which may result in the formation of oxalate stones in the urinary tract. (See also VITAMIN.)... ascorbic acid
See DNA.... deoxyribonucleic acid
A valuable antistaphylococcal antibiotic used both orally and topically. It is particularly useful in osteomyelitis (see BONE, DISORDERS OF).... fusidic acid
One of the NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) that is an analgesic (see ANALGESICS) for mild to moderate pain in RHEUMATOID ARTHRITIS, OSTEOARTHRITIS and other musculoskeletal disorders. Also used for DYSMENNORRHOEA and MENORRHAGIA. It must be used with care as it has several side-effects, in particular diarrhoea and occasional haemolytic ANAEMIA. It must not be used in patients with INFLAMMATORY BOWEL DISEASE (IBD).... mefenamic acid
An antibiotic drug, active against gram-negative (see GRAM’S STAIN) micro-organisms, used to treat and prevent infections of the URINARY TRACT.... nalidixic acid
Nicotinic acid is a member of the vitamin B complex. It is essential for human nutrition, the normal daily requirement for an adult being about 15–20 mg. A de?ciency of nicotinic acid is one of the factors in the etiology of PELLAGRA, and either nicotine acid or NICOTINAMIDE is used in the treatment of this condition. Nicotinic acid also reduces the concentration of blood lipids (see HYPERLIPIDAEMIA).... nicotinic acid
Group of chemicals found in cells and which carry biochemical codes for heredity and day-to-dayfunctioning of cells.... nucleic acid
This is an irritant poison that is used domestically for cleaning purposes. It is also found in many plants including rhubarb and sorrel. Oxalic acid, when swallowed, produces burning of the mouth and throat, vomiting of blood, breathlessness and circulatory collapse. Calcium salts, lime water or milk should be given by mouth. An injection of calcium gluconate is an antidote.... oxalic acid
A crystalline substance sparingly soluble in water that is used externally in ointments and pastes. It has antifungal properties and helps to loosen and remove scales. In high concentrations it is useful in treatment of verrucae (WARTS) and corns (see CORNS AND BUNIONS).... salicylic acid
A drug used in the control of bleeding. It inhibits the activation of PLASMINOGEN and FIBRINOLYSIS, and may be useful when bleeding cannot be stopped – for instance, dental extraction in HAEMOPHILIA. The drug is also useful in MENORRHAGIA.... tranexamic acid
A preparation used in the treatment of cholesterol gall-stones when laparoscopic CHOLECYSTECTOMY and endoscopic biliary procedures cannot be used (see GALL-BLADDER, DISEASES OF).... ursodeoxycholic acid
An organic acid produced by the LIVER when it is rapidly oxidising fatty acids – a metabolic process which occurs, for example, during starvation. The acid produced is then converted to ACETONE, which is excreted.... acetoacetic acid
In our context, a substance having a pH below that of neutral water (7.0) when in solution. Most metabolic waste products are acidic. Sour. See pH... acid
Carbolic acid, or phenol, was the precursor of all ANTISEPTICS. It paralyses and then destroys most forms of life, particularly organisms such as bacteria. It has been superseded by less penetrative and harmful antiseptics.... carbolic acid
One of the bile acids (see BILE), used in the treatment of cholesterol gall-stones for patients with mild symptoms when other modern techniques are unsuitable. (See GALL-BLADDER, DISEASES OF.)... chenodeoxycholic acid
This is responsible for the sharp taste associated with citrus fruits, such as lemons and limes, and other fruits such as currants and raspberries. Although chemically di?erent from, it is similar in action and appearance to tartaric acid, obtained from grapes and other fruits, and similar to malic acid, found in apples and pears.... citric acid
Three acids – arachidonic, linolenic and tinoleic – which are essential for life, but which the body cannot produce. They are found in natural vegetable and ?sh oils and their functions are varied. EFAs have a vital function in fat metabolism and transfer and they are also precursors of PROSTAGLANDINS.... essential fatty acids
See GABA.... gamma aminobutyric acid
An unsaturated fatty acid occurring widely in the glycerides of plants. It is an essential nutrient for mammals, including humans.... linoleic acid
The most common of naturally occurring fatty acids, being present in most fats and oils in the form of triglyceride. It is used in the preparation of OINTMENTS, but not eye ointments.... oleic acid
A yellow crystalline solid substance which is used as a ?xative for tissues being prepared for examination under a microscope; it is also used as a dye.... picric acid
See RNA.... ribonucleic acid
A bisphosphonate drug used in the treatment of osteoporosis and Paget’s disease of bone. The most common side effect is inflammation of the oesophagus, which causes heartburn or difficulty in swallowing. Other side effects can include headache and abdominal pain.... alendronic acid
One of the fatty acids in the body that are essential for growth.... arachidonic acid
A topical drug used to treat mild to moderate acne.... azelaic acid
See ASPIRIN.... acetylsalicyclic acid
Excretion of an acid URINE.... aciduria
A drug used to treat hereditary angio-oedema (see under URTICARIA) – a serious anaphylactic (see ANAPHYLAXIS) reaction of the skin and respiratory tract resulting from a de?ciency in the body’s immunological defence mechanisms (see IMMUNITY).... aminocaproic acid
Chromic acid is used in several industries, particularly in chromium plating. Unless precautions are taken it may lead to dermatitis of the hands, arms, chest and face. It may also cause deep ulcers, especially of the nasal septum and knuckles.... chromic acid
See INDISPENSABLE AMINO ACIDS.... essential amino acids
A potent diuretic, with a rapid onset, and a short duration (4–6 hours), of action. (See THIAZIDES; DIURETICS.)... ethacrynic acid
This is the new, preferred term for essential amino acids – amino acids which are essential for the body’s normal growth and development, but which the body is unable to produce. Nine essential amino acids exist – HISTIDINE, ISOLEUCINE, LEUCINE, LYSINE, METHIONINE, PHENYLALANINE, THREONINE, TRYPTOPHAN, and VALINE – and they are present in foods rich in protein: dairy products, eggs, meat, and liver.... indispensable amino acids
Lysergic acid diethylamide belongs to the ergot group of ALKALOIDS. It has various effects on the brain, notably analgesic and hallucinogenic, thought to be due to its antagonism of 5hydroxytryptamine (5-HT). In small doses it induces psychic states, in which the individual may become aware of repressed memories. For this reason it may help in the treatment of certain anxiety states, if used under skilled supervision. LSD rapidly induces TOLERANCE, however, and psychological DEPENDENCE may occur, although not physical dependence. Serious side-effects include psychotic reactions, with an increased risk of suicide.... lysergic acid diethylamide (lsd)
Also known as mandelamine, a non-toxic keto-acid used in the treatment of infections of the urinary tract, especially those due to the Escherichia coli and the Streptococcus faecalis or Enterococcus. It is administered in doses of 3 grams several times daily. As it is only e?ective in an acid urine, ammonium chloride must be taken at the same time.... mandelic acid
One of the early antituberculous (see TUBERCULOSIS) antibiotics. It tended to cause DYSPEPSIA and has been replaced by newer antituberculous drugs with fewer side-effects. The ?rst-line drugs for tuberculosis are now rifampicin, isoniazid, and ethambutol.... para-amino salicylic acid
See CYANIDE POISONING.... prussic acid poisoning
Foods that produce acid when metabolised. Ash from these foods contains sulphur, phosphoric acid and chlorine, all essential for efficient metabolism. Breads, cereals, cheese, chicken, chocolate, cocoa, coffee, cranberries, eggs, fish, flour, fowl, grain products, lentils, meats (lean), nuts, oats, oatmeal, oysters, pasta, peanuts, peanut butter, pearl barley, plums, prunes, rhubarb, rabbit, rice (white), sugar, sweet corn, tea, veal, wholemeal bread, wheatgerm. ... acid foods
Heartburn, with acid eructations and a sensation of distress in the stomach, chiefly associated with peptic ulcer (duodenal) or gastritis.
Symptoms: local tenderness and stomach gas. The terms hyperacidity and hyperchlorhydria refer to excessive production of hydrochloric acid in the stomach.
Alternatives. For preparation and dosage see remedy entry.
Teas: Agrimony, Balm, Black Horehound, Caraway, Catnep, Celery seeds, Centuary, Chamomile, Dandelion root coffee, Fennel, Irish Moss, Liquorice root, Meadowsweet, Parsley, Quassia, Red Sage. Tablets/capsules. Dandelion, Papaya, Goldenseal. Dosage as on bottle.
Powders: equal parts, Slippery Elm, White Poplar, Meadowsweet. Mix. 500mg (two 00 capsules or one- third teaspoon) thrice daily and when necessary.
Tinctures. Formula: Dandelion 1; Meadowsweet 1; Nettles 1; Goldenseal quarter. Dose: 1-2 teaspoons in water thrice daily before meals.
Practitioner prescription. Dec Jam Sarsae Co conc (BPC 1949) 1 fl oz (30ml); Liquid Extract Filipendula 1 fl oz (30ml); Liquid Extract Taraxacum off. Half a fl oz (15ml); Ess Menth Pip 0.05ml. Aqua to 8oz (240ml). Sig: one dessertspoon (8ml) in warm water before meals. (Barker).
Diet: lacto-vegetarian. Garlic. Celery. Dried raw oats. Regular raw food days. Low fat. Powdered kelp in place of salt. Paw paw fruit. Regulate bowels.
Note: In view of the finding of gastric carcinoid tumours in rodents subjected to long-term anti-secretory agents, caution needs to be exercised over the long-term use of antacids that powerfully suppress the gastric juices. ... acidity
A polyunsaturated fatty acid; an essential ingredient in the body’s production of prostaglandins. Present naturally in mother’s milk. The body produces GLA from linoleic acid present in food as an essential fatty acid (EFA). Vital to growth, cell structure and cardiac health. Sources: Evening Primrose oil; Sunflower seed oil, Borage and Blackcurrant. Preparations from the fermentation of rotten carrots. Helps lower blood pressure and prevent cholesterol build-up in the blood. ... gamma linolenic acid (gla)
Regurgitation of acidic fluid from the stomach into the oesophagus due to inefficiency of the muscular valve at the lower end of the oesophagus. Also known as gastro-oesophageal reflux disease (GORD), acid reflux may inflame the oesophagus, resulting in heartburn due to oesophagitis. It may occur in pregnancy and often affects overweight people.... acid reflux
The active ingredient of many sunscreen preparations. Its abbreviation is.... para-aminobenzoic acid
see aspirin.... acetylsalicylic acid
n. abnormally high blood acidity. This condition may result from an increase in the concentration of acidic substances and/or a decrease in the level of alkaline substances in the blood. See also acidosis. Compare alkalaemia.... acidaemia
a technique for creating a mechanical bond between resin-based materials and the enamel of teeth; it is used to retain and seal the margins of composite fillings, to retain brackets of fixed orthodontic appliances, and to retain resin-based *fissure sealants and adhesive bridges. Phosphoric acid is used to create a porous surface into which a bonding agent can flow.... acid-etch technique
adj. 1. describing bacteria that have been stained and continue to hold the stain after treatment with an acidic solution. For example, tuberculosis bacteria are acid-fast when stained with a *carbol fuchsin preparation. 2. describing a stain that is not removed from a specimen by washing with an acidic solution.... acid-fast
Substances found in all living matter that have a fundamental role in the propagation of life. Nucleic acids provide the inherited coded instructions (or “blueprint”) for an organism’s development.
There are 2 types of nucleic acid: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). In all plant and animal cells, including human cells, DNA permanently holds the coded instructions, which are translated and implemented by RNA. DNA is the main constituent of chromosomes, which are carried in the nucleus (central unit) of the cell.
DNA and RNA are similar in structure, both comprising long, chain-like molecules. However, DNA usually consists of 2 intertwined chains, whereas RNA is generally single-stranded.
The basic structure of DNA has been likened to a rope ladder, the chains forming the 2 sides, with interlinking structures in between forming the rungs.
The ladder is twisted into a spiral shape called a double helix.
Each DNA chain has a “backbone” consisting of a string of sugar and phosphate chemical groups. Attached to each sugar is a chemical called a base, which can be any of 4 types (adenine, thymine, guanine, and cytosine) and forms half a rung of the DNA ladder. The 4 bases can occur in any sequence along the chain. The sequence, which may be many millions of individual bases long, provides the code for the activities of the cell (see genetic code).
RNA is like a single strand of DNA; the main difference is that the base thymine is replaced by another base, uracil.When a cell undergoes mitotic (see mitosis) division, identical copies of its DNA must go to each of the 2 daughter cells. The 2 DNA chains separate, and 2 more chains are formed, side by side with the original chains. Because only certain base pairings are possible, the new double chains are identical to the original DNA molecule. Each of a person’s cells carries the same DNA replica that was present in the fertilized ovum, so the DNA message passes from one generation of cells to the next.... nucleic acids
(acidophilic) adj. 1. (in histology) describing tissues, cells, or parts of cells that stain with acid dyes (such as eosin). See also adenoma. 2. (in bacteriology) describing bacteria that grow well in acid media.... acidophil
an organic compound containing an amino group (–NH2) and a carboxyl group (–COOH). Amino acids are fundamental constituents of all *proteins. They are classified as *essential amino acids, i.e. those that cannot be synthesized by the body, and nonessential amino acids, which can be synthesized by the body. Certain amino acids present in the body are not found in proteins; these include *citrulline, *ornithine, *taurine, and *gamma-aminobutyric acid.... amino acid
(aspartate) see amino acid.... aspartic acid
an antiseptic, active against fungi and bacteria, used as a preservative in foods and pharmaceutical preparations and, combined with salicylic acid, in the form of an ointment (Whitfield’s ointment) for the treatment of ringworm.... benzoic acid
(cholalic acid) see bile acids.... cholic acid
see Krebs cycle.... citric acid cycle
a drug that interferes with the *penicillinases that inactivate *beta-lactam antibiotics, such as *amoxicillin or *ticarcillin. Combined with the antibiotic, clavulanic acid can overcome drug resistance.... clavulanic acid
see bile acids.... deoxycholic acid
an *amino acid that is essential for normal growth and development but cannot be synthesized by the body. Essential amino acids are obtained from protein-rich foods in the diet, such as meat, fish, eggs, and dairy products. Adults require eight essential amino acids: leucine, isoleucine, valine, phenylalanine, threonine, methionine, tryptophan, and lysine. Children require an additional nine, as their body’s requirement is greater than can be synthesised by it: tyrosine, glycine, cysteine, arginine, proline, histidine, glutamine, serine, and asparagine.... essential amino acid
an organic acid with a long straight hydrocarbon chain and an even number of carbon atoms. Fatty acids are the fundamental constituents of many important lipids, including *triglycerides. Some fatty acids can be synthesized by the body; others, the *essential fatty acids, must be obtained from the diet. Examples of fatty acids are palmitic acid, oleic acid, and stearic acid. See also fat; saturated fatty acid; unsaturated fatty acid.... fatty acid
a derivative of folic acid involved in purine synthesis. It is used to reverse the biological effects of methotrexate and other *dihydrofolate reductase inhibitors and so to prevent excessive toxicity. This action is termed folinic acid rescue. Folinic acid has a potentiating effect with *fluorouracil, with which it is often used.... folinic acid
a sugar acid derived from glucose. Glucuronic acid is an important constituent of *chondroitin sulphate (found in cartilage) and *hyaluronic acid (found in synovial fluid).... glucuronic acid
(glutamate) see amino acid; neurotransmitter.... glutamic acid
(GAD) a common enzyme that, because of similarities to certain bacterial proteins, can provoke an autoimmune reaction against the beta cells of the pancreas (see islet cell antibodies) progressing to type 1 *diabetes mellitus.... glutamic acid decarboxylase
see bile acids.... glycocholic acid
a derivative of *histamine that was formerly used to test for acid secretion in the stomach in conditions involving abnormal gastric acid secretion, such as *Zollinger-Ellison syndrome.... histamine acid phosphate
a product formed during the metabolism of the amino acids phenylalanine and tyrosine. In normal individuals homogentisic acid is oxidized by the enzyme homogentisic acid oxidase. In rare cases this enzyme is lacking and a condition known as *alcaptonuria, in which large amounts of homogentisic acid are excreted in the urine, results.... homogentisic acid
an acid *mucopolysaccharide that acts as the binding and protective agent of the ground substance of connective tissue. It is also present in the synovial fluid around joints and in the vitreous and aqueous humours of the eye.... hyaluronic acid
(prussic acid) an intensely poisonous volatile acid that can cause death within a minute if inhaled. It has a smell of bitter almonds. See cyanide.... hydrocyanic acid
(5-HIAA) a metabolite of *serotonin, the most common secretion product of *carcinoid tumours. Measured over 24 hours in the urine, this is the most reliable screening test for such tumours.... 5-hydroxyindoleacetic acid
excessive plasma acidity due to an accumulation of lactic acid. This may be caused by a variety of illnesses, including heart failure or severe dehydration. It can also be caused by the accumulation of *biguanide drugs used for treating type 2 *diabetes mellitus, particularly when kidney failure is present. Biguanides (see metformin) should therefore not be used to treat patients who have established kidney disease or heart failure or who are dehydrated.... lactic acidosis
see essential fatty acid.... linolenic acid
a sulphur-containing compound that can be readily interconverted to and from its reduced form, dihydrolipoic acid. Lipoic acid functions in carbohydrate metabolism as one of the *coenzymes in the oxidative decarboxylation of pyruvate and other ?-keto acids.... lipoic acid
(LSD) an illegal hallucinogenic drug that was formerly used to aid treatment of certain psychological disorders. Side-effects include digestive upsets, dizziness, tingling, anxiety, sweating, dilated pupils, muscle incoordination and tremor. Alterations in sight, hearing, and other senses occur, psychotic effects, depression, and confusion are common, and tolerance to the drug develops rapidly. Because of these toxic effects, LSD is no longer used clinically. See Appendix 12 for a list of street names for illicit drugs.... lysergic acid diethylamide
(methylmalonic acidaemia, aminoacidopathy) a defect of amino acid metabolism causing an excess of methylmalonic acid in the urine and blood. There are two types: one is an *inborn error of metabolism due to a deficiency of the enzyme methylmalonyl-CoA mutase; the other is an acquired type due to deficiency of vitamin B12, which results in defective synthesis of adenosylcobalamin (a cofactor in this metabolic process).... methylmalonic aciduria
a strong corrosive mineral acid, HNO3, the concentrated form of which is capable of producing severe burns of the skin. Swallowing the acid leads to intense burning pain and ulceration of the mouth and throat. Treatment is by immediate administration of alkaline solutions, followed by milk or olive oil.... nitric acid
(n-3 fatty acids) polyunsaturated fatty acids with a double bond at the third carbon atom in the chain. Omega-3 fatty acids are essential for brain development and are also associated with many health benefits, including protection against heart disease and possibly stroke and inflammatory conditions. There are three major types: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). The main source of EPA and DHA is fish oils. Vegetarians rely on EPA and DHA being synthesized by the body from dietary sources of ALA. See also essential fatty acids.... omega-3 fatty acids
see osmium tetroxide.... osmic acid
see fatty acid.... palmitic acid
(PAS reaction) a test for the presence of glycoproteins, polysaccharides, certain mucopolysaccharides, glycolipids, and certain fatty acids in tissue sections. The tissue is treated with periodic acid, followed by *Schiff’s reagent. A positive reaction is the development of a red or magenta coloration.... periodic acid–schiff reaction
see hydrocyanic acid.... prussic acid
see folate.... pteroylglutamic acid
(pyruvate) a compound, derived from carbohydrates, that may be oxidized via a complex series of reactions in the *Krebs cycle to yield carbon dioxide and energy in the form of ATP.... pyruvic acid
a *fatty acid in which all the carbon atoms are linked by single bonds and the molecule is unable to accept additional atoms (i.e. it cannot undergo addition reactions with other molecules). These fats occur mainly in animal and dairy products, and a diet high in these foods may contribute to a high serum cholesterol level, which may increase the risk of *coronary artery disease. Compare unsaturated fatty acid.... saturated fatty acid
an amino sugar. Sialic acid is a component of some *glycoproteins, *gangliosides, and bacterial cell walls.... sialic acid
see fatty acid.... stearic acid
a powerful corrosive acid, H2SO4, widely used in industry. Swallowing the acid causes severe burning of the mouth and throat and difficulty in breathing, speaking, and swallowing. The patient should drink large quantities of milk or water or white of egg; gastric lavage should not be delayed. Skin or eye contact should be treated by flooding the area with water.... sulphuric acid
see bile acids.... taurocholic acid
an *astringent used for a variety of skin conditions. It is also applied topically to produce sloughing, especially for the removal of warts.... trichloracetic acid
an antifungal agent, applied to the skin for the treatment of athlete’s foot.... undecenoic acid
a *fatty acid in which one (monounsaturated) or many (polyunsaturated) of the carbon atoms are linked by double bonds that are easily split in chemical reactions so that other substances can connect to them. These fats occur in fish and plant-derived foods, and a diet high in unsaturated fats is associated with low serum cholesterol levels. Compare saturated fatty acid.... unsaturated fatty acid
see sodium valproate.... valproic acid
(VMA) a metabolite of *catecholamines excreted in abnormal amounts in the urine in conditions of excess catecholamine production, such as *phaeochromocytoma. The measurement of VMA levels in a 24-hour urine sample was formerly used as a screening test for this condition, but in the UK it has been largely superseded by the urinary metanephrine test (see metanephrine and normetanephrine).... vanillylmandelic acid
(zolendronate) a *bisphosphonate drug that is used to treat Paget’s disease and malignant *hypercalcaemia and is also establishing a role in treating bone metastases, both in terms of symptom relief and preventing bone fractures.... zoledronic acid
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